Pharmacokinetics of amphotericin B colloidal dispersion in critically ill patients with cholestatic liver disease.
نویسندگان
چکیده
The pharmacokinetics of lipid-bound and liberated amphotericin B (AMB) was assessed in 11 critically ill patients with cholestatic liver disease (CSLD) and in 9 subjects with normal liver function treated with AMB colloidal dispersion (ABCD). Exposure to lipid-bound AMB was higher in patients with CSLD. Levels of liberated AMB were elevated by CSLD only after the first dose, whereas its pharmacokinetics was unaffected at steady state. The standard dosage of ABCD is probably adequate for patients with CSLD.
منابع مشابه
Amphotericin B lipid formulations in critically ill patients on continuous veno-venous haemofiltration.
OBJECTIVES The pharmacokinetics of lipid-formulated amphotericin B (AMB), and of AMB that has dissociated from its lipid moiety and bound to lipoproteins in plasma, were separately determined in critically ill patients. PATIENTS AND METHODS Eleven patients required continuous veno-venous haemofiltration (CVVH). Five of them were treated with liposomal AMB (AmBisome) and seven with AMB colloid...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 56 10 شماره
صفحات -
تاریخ انتشار 2012